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4.1 Central nervous system effects GLP-1R is distributed throughout various regions in the brain, with the highest concentrations being found in the hippocampus and cerebral cortex, areas mainly responsible for cognitive function, memory improvement, and learning ( GLP-1RA plays a key role in promoting CNS health in conditions like T2DM and lowering the risk of stroke ( In the brain, GLP-1RAs perform anti-inflammatory, antioxidant, and anti-apoptotic functions ( Appetite regulation is a common function of many GLP-1RAs, which act on the hypothalamus- the center of hunger and energy balance- and promote feelings of fullness, eventually leading to weight loss ( 4.2 Cardiovascular system effects GLP-1 receptor agonists have a very close connection with cardiovascular outcomes and prevention of many diseases