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Therefore, profound understanding of the molecular mechanisms by which these master transcriptional regulators exert their function will potentiate the development of a pan-disease therapeutic regime

17,18 NAD + has been detected in the nucleus and in almost all cytoplasmic organelles

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After 2, 4, and 6 days of culture, the cell number in the PDL9 group was significantly lower than that in the PDL3 group (Figure 1C), which indicated that the proliferative ability of senescent chondrocytes was significantly decreased