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When to start here: If you have a good relationship with your primary care doctor and theyre comfortable managing GLP-1 medications, this is the simplest path

Outcomes The primary endpoint was time in the target glucose range of 3.910.0 mmol l 1 (time in range) between semaglutide (at maximum tolerated dose) and placebo, over the 28 days of AID use

Although leptin deficiency does not fully recapitulate common human obesity, these findings highlight pronounced sex-specific differences in skeletal muscle and adipose adaptations to semaglutide-induced weight loss and underscore the importance of considering biological sex when evaluating the metabolic and body composition effects of GLP-1 receptor agonist therapies Supplement Figures Acknowledgment This research is supported by NIH grants (DK107397, DK127979, GM144613, and AG074535 to K.F., CA278826 to K.H.F, CA286584 and AG065993 to A.H.C), and the Grant-in-aid for Japan, Society for Promotion of Science (JSPS) Fellows (24KJ2039 to T.K.)

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