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6365 Additionally, it was demonstrated that exendin-4 is also mediated by the adsorptive transcytosis across brain endothelial cells

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Mifepristone, a glucocorticoid and progesterone receptor antagonist, has been shown to improve insulin sensitivity and decrease fasting plasma glucose concentrations and HbA1c concentrations in patients with Cushings disease and impaired glucose tolerance or diabetes mellitus (27)

These often relate to slowed stomach emptying and dose escalation, but persistent or severe symptoms need medical review