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Some of the most recent research theorizes that all cells can produce melatonin in their mitochondria.[ref] Extra-pineal melatonin doesnt affect the circadian clock or the sleep-wake cycle

T2DM is characterized by a chronic proinflammatory state marked by the overexpression of cytokines, such as interleukin-1, interleukin-6, and tumor necrosis factor-alpha, alongside chemokines and other proinflammatory mediators, which contribute to insulin resistance.108 Elevated concentrations of these inflammatory cytokines have been detected in the plasma and cerebrospinal fluid of patients with AD,109 and postmortem analyses revealed an inflammatory milieu within the AD brain,110 implicating inflammation as a contributory factor in the pathogenesis of dementia

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