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Given that metformin is likely to have only a small impact on DPP4 activity, it is likely that the main impact of metformin on GLP-1 is to increase GLP-1 secretion

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68,69 Investigators have noted lower GSH concentrations to be associated with the combination of advanced age and increased risk of chronic diseases such as chronic renal failure, malignant disorders, diabetes, alcoholism, Parkinson's disease, and cataract formation