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Many people take vitamin E supplements in the hopes of improving their immune system, decreasing their risk of cancer, or strengthening their hair, skin, and nails via the vitamins antioxidant and potentially anti-aging effects ( However, vitamin E supplements are unnecessary and provide little benefit unless you are deficient in the vitamin ( People on low fat diets or those with disorders that affect their ability to digest and absorb fat, such as Crohns disease or cystic fibrosis, may be at an increased risk of vitamin E deficiency ( Summary Unless youre vitamin E deficient, you likely dont need to supplement with it

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Bedford (1985), "On the Nature of a Defect in Cells from Individuals with Ataxia-Telangiectasia.", Science 227(4694):15891591

both antibiotic use and germ-free conditions suppress the expression of CYP7A1 and CYP27A1, key enzymes involved in BA production based on animal mechanistic studies (Chiang and Ferrell, 2019)