Following an apoptotic stimulus, Bax is activated and translocates to the mitochondria, where it undergoes a conformational change and inserts into the OMM
6 8 Lesions tend to regress after therapy is discontinued
Up to 75% of women experience hot flashes or night sweats during their menopause journey, with symptoms nearly five times more prevalent in perimenopause than premenopause Declining estrogen levels disrupt the hypothalamus, causing the body's internal thermostat to malfunction and trigger sudden sweating episodes Alcohol, caffeine, spicy foods, stress, and warm bedroom temperatures can significantly worsen nocturnal sweating Practical solutions include moisture-wicking sleepwear, cooling bedding, and keeping bedroom temperatures between 60-67F Hormone replacement therapy and non-hormonal options exist for severe cases, but tracking symptoms helps doctors provide accurate diagnoses Waking up drenched in sweat at 3 AM is exhausting, frustrating, and far more common than most women realize
N Engl J Med (2021) 384(7):599609