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This is a theoretical concern raised by the biology, not a demonstrated harm in humans for either compound, and it should be described as exactly that an unresolved question that the absence of long-term human data leaves open, not a proven risk and not a reason for false reassurance either

Therefore, appetite reduction, early fullness, constipation, diarrhea, and injection-site reactions may also be reported depending on the study

Clinical symptoms are insufficient to guide appropriate treatment selection 5 and, presently, treatments are therefore selected empirically relying on a trial and error approach 6,7