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Possible Side Effects: Mild redness Temporary dryness Slight irritation in sensitive skin To minimize risks: Always do a patch test Use sunscreen daily Avoid mixing with strong chemical exfoliants initially Follow recommended usage instructions If irritation persists, discontinue use and consult a dermatologist

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The idea that if a drug is displaced from plasma proteins it would increase the unbound drug concentration and increase the drug effect and, perhaps, produce toxicity seems a simple and obvious mechanism