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Thus, carnosine readily forms a charge-transfer complex with oxygen free radicals (e.g., superoxide radical, hydroxyl radicals, peroxyl radicals, and nitric oxide), non-radical ROS (e.g., peroxynitrite, hypochlorous acid, singlet oxygen, and H 2 O 2 ), and deleterious aldehydes (e.g., malondialdehyde and formaldehyde) to confer anti-oxidative effect and protect cell membrane and intracellular organelles (e.g., mitochondria) from damage (Kohen et al

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however, the trial product estimand at week 52 showed that oral semaglutide reduced body weight significantly more than empagliflozin (4.7 versus 3.8 kg

Table 1), while no significant differences in other enzymatic activities were found (Figs