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Patients with copper sensitivity may experience more pronounced injection site reactions, and this is the primary clinical indicator that leads to protocol adjustment or discontinuation

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These findings corroborate evidence of decreased Complex II protein levels and OXPHOS activity, which is a marker for mitochondrial FAD in muscle of patients with severe neuromuscular phenotype and novel variants in SLC25A32 [30,31]

Proc Natl Acad Sci USA 108:E450E458 Barberon M, Dubeaux G, Kolb C, Isono E, Zelazny E, Vert G (2014) Polarization of iron-regulated transporter 1 (IRT1) to the plant-soil interface plays crucial role in metal homeostasis