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Relaxation induced by each concentration of BPC 157 was measured after the response reached steady-state, and the value was expressed as a percentage of the initial vasoconstrictor-induced tone

The peptide diffuses laterally through interstitial fluid before entering systemic circulation, meaning a significant fraction reaches dermal fibroblasts at concentrations 35 higher than what systemic distribution via IM would achieve

Without targeted research, we cannot make blanket claims of safety

doi: 10.3389/fphar.2022.910292 Received 01 April 2022 Accepted 03 August 2022 Published 29 August 2022 Volume 13 - 2022 Edited by Seung-Yeol Park, Pohang University of Science and Technology, South Korea Reviewed by Amit Krishna De, Indian Science Congress Association, India Jinke Wang, Southeast University, China Updates Copyright 2022 Li, Long, Zhou, Luo, Xu and Gao