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5.1.2 Histone modification disruptions 5.1.2.1 Repressive and activating chromatin marks EED exposure systematically alters the chromatin landscape through modifications to key histone marks
[DOI] [PubMed] [Google Scholar] 174.Chowdhury A., Boukezzi S., Costi S., Hameed S., Jacob Y., Salas R., Iosifescu D.V., Han M.-H., Swann A., Mathew S.J., et al
But it goes way beyond that These melanopsin intrinsically photosensitive retinal ganglion cells also project to areas of the brain like the habenula, which can trigger negative affect, negative mood They can trigger the release of dopamine or the suppression of dopamine, the release of serotonin, the suppression of serotonin, and so theyre not just cells for setting your circadian clock They also have a direct line (literally one synapse away) into the structures of the brain that we know powerfully control mood The mechanistic basis for all this is there Theres just a couple of other key points to understand for people to really be able to digest the data in this paper fully 3 There are basically two types of stimuli that these cells respond to Would you like access to extensive show notes and references for this podcast (and more)
