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52,54-56 A three-month study of a supplement containing a mixture of curcuminoids (at 0.43 mg per 1,000 kilocalories in the diet) plus hydrolyzed collagen and green tea extract in 42 adult dogs with osteoarthritis found the supplement did not improve lameness or owners subjective assessment of mobility, but significantly reduced veterinarians subjective assessment of pain upon movement of affected limbs

This application originally an incidental finding in early tanning research has been extensively studied and led directly to the development of PT-141 (Bremelanotide) as a selective MC4R-targeting compound

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