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Normally, the kidney and liver rely heavily on oxidative phosphorylation for energy production as both the liver and the kidney are dense with mitochondria

However, in Hfe knockout mice, a wide range of mutations can cause various degrees of iron overload in several organs, including the liver and heart [65]

A protein was assigned to the glutathione system if any one of the above mentioned clusters was the first hit in RPS-BLAST results of that protein against a database of all downloaded PSSMs