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Evidence includes observations of reduced oxidative stress markers, improved mitochondrial parameters, and decreased indicators of DNA damage

Home-based aerobic exercise and resistance training for severe chronic kidney disease: a randomized controlled trial

A phase 2 trial published in the New England Journal of Medicine showed average weight loss of over 24% at 48 weeks, and the first phase 3 results in December 2025 suggested that average weight loss could be around 28 to 29%