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In April 2026, The Foundation for Prader-Willi Research (FPWR) announced a venture philanthropy investment in ConSynance Therapeutics to support the advancement of CSTI-500, ConSynance s investigational therapy for the treatment of behavioral dysregulation and hyperphagia in PWS

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Small pilot studies in women with PCOS have suggested potential benefits on insulin sensitivity and hormonal parameters, but robust, large-scale trials examining weight loss outcomes specifically are lacking

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