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Anyone reading about Dihexa should weigh it against that backdrop: the pharmacology is interesting in animals, but the daily habits with real human data are the ones with an actual track record

They discuss the benefits of intentionally introducing discomfort into daily life, from taking the stairs to disconnecting from technology

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The initial model was rigid-body fitted into the consensus EM density map via UCSF Chimera 1.14 32 , followed by manual adjustment using ISOLDE 33 embedded in UCSF ChimeraX 1.6 34