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The subsequent downstream signaling cascade initiated from substrates of the insulin receptor activates kinases and transcription factors vital in promoting cell metabolism, neuronal growth and differentiation, gene transcription, synaptic plasticity, and neuroprotection [133] (Fig

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Despite fasting for over 10 hours and having no complaints of gastric symptoms prior to the EGD, the procedure had to be halted because of large amounts of food in the gastric body