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Laboratory & third party tested

has received funding from the Wellcome Trust (221604/Z/20/Z) and Barts Charity Grants (MRC0215, G-002145)

*Binding to IGF-1 Receptor*: IGF-LR3 binds to the IGF-1 receptor, activating signaling pathways that promote cell growth and survival

We then examine the distinct lipid metabolic patterns in different immune cells, detailing how this reprogramming drives dysfunction in antitumor subsets such as CD8 + T cells and natural killer cells and how it promotes immunosuppressive populations such as tumor-associated macrophages and myeloid-derived suppressor cells