This does not exclude the possibility of skin sensitivity occurring in a subset of patients, particularly as Phase 3 trials enrol larger and more diverse populations
These are once weekly injections as compared to conventional growth hormone which has to be taken as daily injections
In addition, many AD trials do not target the disease until it is already in a mild to moderate stage, and they do not use a patient stratification system based on biomarkers
[PubMed] Compound 4: TB-500 Research Findings Cellular G-actin sequestration, cytoskeletal remodeling, keratinocyte and endothelial cell migration in Boyden chamber and scratch-wound assays Molecular Integrin-linked kinase (ILK) signaling, PINCH protein interactions, NF-B pathway modulation, MMP-2/MMP-9 expression in cultured fibroblasts and keratinocytes Systemic (Preclinical) Rodent models of dermal wound repair (normal, aged, and db/db diabetic), corneal injury, and cardiac ischemia-reperfusion using full-length TB4 with parallel fragment studies References (TB-500): Malinda KM, et al
