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A escala global, la obesidad provoca ms de 4 millones de fallecimientos cada ao

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Glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide (marketed under the highly recognizable brand names Ozempic and Wegovy ) and dual GIP/GLP-1 receptor agonists like tirzepatide (Mounjaro, Zepbound) have demonstrated exceptional clinical efficacy for glycemic control, sustainable weight loss, and altering the surgical approach to global obesity

However, oxidative stress-mediated changes in cellular machinery allow Nrf2 to escape the degradation pathways and translocate to the nucleus