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GLP-1-based compounds work primarily through appetite suppression, and the weight loss they produce includes significant lean mass loss (approximately 40% of total weight lost is lean tissue based on STEP trial data)

Participants showed improvements in multiple aging markers, including oxidative stress, mitochondrial function, muscle strength, and even walking speed

Considering the potential impacts of stress on various aspects of mouse physiology, any mouse subjected to acute stress (sudden heavy drop owing to operational error, and injury owing to injection error) was also excluded