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Funding The work was supported by Natural Science Foundation of Liaoning Province (2019-MS-075), Liaoning Revitalization Talents Program (XLYC1807124), Dalian Technology Innovation Program (2019J13SN109) and Health Commission of Dalian (1811014)

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Aldehyde dehydrogenase 2 in the mitochondria metabolizes acetaldehyde, consuming NAD + and generating reactive oxygen/nitrogen species (Gao et al