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185 papers were identified of which 58 were duplicates and 118 were excluded (unrelated n=83, syndromic/genetic GHD n=17, non-English n=13, abstract n=1, case report n=1)

The anti-inflammatory properties of glucagon like peptide-1 receptor agonists The glucagon like peptide-1 receptor agonists (GLP-1 RAs) are a glucose-lowering class of drugs that acts by mimicking the native GLP1 action, a peptide hormone synthesized by bowel endocrine L-cells and physiologically degraded by dipeptidyl-peptidase 4

Makary singled out the ad in last weeks Journal of the American Medical Association, calling it a brazen example of how advertising is contributing to Americas culture of overreliance on pharmaceuticals for health. Hims and similar companies initially sold cheap generic versions of drugs for hair loss, erectile dysfunction and other health issues

A comprehensive analysis is imperative before considering this peptide for therapeutic applications