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Under constant exposure, receptors are pulled off the cell surface and become less responsive over time (receptor desensitization). Higher doses maintain more signal against that fade

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available only through 503A compounding pharmacies under physician supervision Typical research dose range / 200-800 mcg/day subcutaneously, cycled 4-8 weeks Known lethal dose (LD50) / Not established in any species studied to date Rodent acute toxicity ceiling / No mortality observed at doses exceeding 10 mg/kg intraperitoneally Most reported excess-dose symptoms / Nausea, lightheadedness, flushing, injection-site irritation Organ toxicity at supratherapeutic doses / Not demonstrated in published preclinical literature Antidote availability / No specific antidote exists

Capsular contracture occurs when the scar tissue around the breast implant becomes hard, which puts pressure on the implant and can even displace it