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Off-Label Use: What Clinicians Should Consider Despite the absence of an approved indication, some pediatric obesity specialists have reported considering off-label GLP-1 receptor agonist use in select children aged 10 to 11 with severe obesity (BMI at or above the 120th percent of the 95th percentile) and weight-related comorbidities such as type 2 diabetes, obstructive sleep apnea, or nonalcoholic steatohepatitis

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