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But apart from its action on insulin, GIP is also believed to improve the bodys long-term lipid storage, such that it reduces fat accumulation in the skeletal muscles and organs.14 This dual activity is likely what accounts for tirzepatides superlative efficacy for weight loss in clinical studies

Mechanism of Action of GLP- 1 in Obesity The function of GLP- 1 in controlling feeding behavior and energy balance was investigated in rats

Reduced appetite is the intended effect, though it sometimes feels too extreme

This means getting your doctor to write a detailed letter explaining your medical need for the medication