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These symptoms may indicate a separate condition requiring evaluation, such as infection or medication intolerance, rather than a typical GLP-1 adjustment response

[7] [8] When taken orally, the substantial proportion that remains unabsorbed in the gastrointestinal tract may directly interact with intestinal microorganisms, potentially causing shifts in microbial populations

Gough SC, Bode BW, Woo VC, et al

A mechanistic review of GLP-1 receptor structure-function relationships published this year underscores why biased agonists like ecnoglutide could set new dosing and efficacy benchmarks [Nature Reviews Drug Discovery]