does glp 1 cross the blood brain barrier Glucagon-like peptide-1 (GLP-1), released from intestine, informs does glp-1 cross the blood

In summary, we report evidence from two major studies demonstrating that metformin treatment leads to a sustained and long term increase in circulating total GLP-1 levels in non-diabetic individuals independent of changes in weight and glycaemia, while metformin therapy is also associated with higher fasted total and active GLP-1 in diabetic patients, independent of weight and glycaemia

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doi: 10.1210/en.2007-1142