semaglutide recombinant synthesis Synthetic Routes Semaglutide (Ozempic and Wegovy) Manufacturing

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The nucleotide sequence of semapeptide (nucleotide sequence) is: GAG GGC ACC TTC ACC AGC GAC GTT AGC AGC TAT CTG GAG GGC CAG GCG GCG AAA GAA TTT ATT GCG TGG CTG GTT CGT GGT CGT GGC

The fermentation medium further comprises acids selected from citric acid, boric acid and the like or combination thereof

An embodiment of the present invention provides a process for the purification of Semaglutide by RP-HPLC comprising aqueous H 2 SO 4 as mobile phase A and Acetonitrile: aqueous H 2 SO 4 as mobile phase B