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Abundant evidence indicates that inflammation is important in the progression of DKD[97]

While radiation induces ROS production that has a key role in induction of DNA double-strand breaks and activation of apoptosis signaling pathways, recent studies have shown that treatment with L-carnitine and its derivatives as potent antioxidants can inhibit DNA damage and activate DNA-repair genes through ROS reduction (65)

In addition, Nair et al., [56] reported that vitamin C, -tocopherol, - and -carotenes, lutein and lycopene are exhausted in peptic ulcer patients irrespective of H.pylori status.Such micronutrient antioxidants are known to protect the gastroduodenal mucosa by scavenging ROS

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