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Fourth, observational studies remain susceptible to residual confounding and treatment-selection bias despite statistical adjustment

Preclinical studies in rodents and nonhuman primates show that exendin-4 (EX-4), and other GLP-1RAs (eg, dulaglutide, liraglutide, semaglutide) reduce alcohol intake and other alcohol-related outcomes in different rodent models and paradigms [55]