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In MCAS, mast cellswhich line the blood vessels, nerves, and mucosal tissuesbecome hyper-responsive, inappropriately releasing massive amounts of histamine, cytokines, and other inflammatory mediators in response to minor environmental or internal triggers

This holistic approach recognizes obesity as a root cause rather than a consequence, aiming to improve overall patient health and simultaneously reduce the burden of multiple chronic diseases. However, Ortiz believes it is too early to take an obesity first approach for autoimmune disease

Placental inflammation and viral infection are implicated in second trimester pregnancy loss

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