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Cell 17 (9), 38703880

Mycotoxin concentrations in rice from three climatic locations in Africa as affected by grain quality, production site, and storage duration

Notably, nearly half are processed by CYP3A4 and CYP3A5 specifically, with another quarter handled by CYP2C8 or CYP2C9 Conversely, drugs containing a carboxylic acid functional group may pose a lower risk of DILI, as they are typically metabolized to acyl glucuronides that are readily excreted ( Fig

Within the nucleus, NRF2 binds to promoter regions of target genes which contain antioxidant response element (ARE) sequences, ultimately inducing the transcription of cytoprotective genes, i.e., those encoding for phase II detoxification enzymes and antioxidants