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GLP-1 helps regulate appetite, food intake, and blood sugar levels

That hormone binds to receptors on certain cells, triggering the body to suppress glucagon, release insulin, and slow digestion

Edited by: Scriver CR, Beaudet AL, Sly WS, Valle D

In support of this, we found that the effect of liraglutide to increase alpha-cell GLP-1 expression necessitates intact beta-cell GLP-1R signaling ( Figure 5 In comparison to GLP-1R agonists, DPP-IV inhibitors decrease the enzymatic degradation of endogenously produced GLP-1, thereby potentiating incretin signaling pathways, albeit with lower potency than GLP-1R agonists, yet fewer adverse effects ( In vitro studies performed on mouse and human islets validate that DPP-IV inhibitors can mediate direct effects on islet hormones ( Figure 4 )