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And small peptide GLP-1 analogues have been demonstrated to cross BBB via peripheral administration, including LG, lixisenatide and exendin-4 ( Analyzing cerebrospinal fluid (CSF), ventricular fluid (VF), and postmortem brain tissue by means of multiplex bead-based ELISAs, the results of the experiment further suggested that there are fifteen cytokines whose levels are elevated in CSF and brain in the course of early-stage AD ( Box 2 , suggesting that GLP-1 suppresses inflammatory responses by inhibiting the MAPKs signaling pathway ( Figure 2
Pooled analysis reported statistically significant effect on hypoglycemia outcomes from treatment with GLP-1RA versus placebo [RR=0.70, 95% CI (0.57, 0.87), p =0.001], showed that the risk of hypoglycemia was about 30% lower in the GLP-1RA treatment group than the placebo group
