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GTP cyclic hydrolase 1 (GCH1) synthesizes tetrahydrobiopterin (BH4) and dihydrobiopterin (BH2), of which BH4 has been shown to act as a direct radical-trapping antioxidant and to participate in ubiquinone synthesis to inhibit ferroptosis [46, 47]

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Gentle, wall-directed addition protects the peptide structure

Based on limited human pharmacology data, ipamorelin appears relatively selective, with less pronounced effects on cortisol and prolactin secretion compared with some other GH secretagogues though this selectivity has not been extensively validated in large human trials