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In addition, there is evidence that pioglitazone reduces the risk of MI and acute coronary syndrome in patients with cardiovascular diseases (CVD) and patients with type 2 diabetes who had previous myocardial infarction [220,221,222]

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Tolvaptan, which is a V2-receptor antagonist, has been demonstrated in experimental studies and a large randomized controlled trial involving 1,445 patients with autosomal dominant PKD to limit the progression of the disease

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