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As for the secondary outcome measures of gastrocnemius muscle mass and flexion foot contracture, there was a significant decrease in muscle mass seen in the right hind limb that underwent sciatic nerve transection, in comparison to the left hind limb that was not operated on

This would include comparative preclinical studies using standardized models of proteinopathy and metabolic dysfunction to define class-specific mechanisms, followed by early-phase human trials incorporating pharmacokinetic and biomarker endpoints of brain target engagement

Despite good discriminative performance, the complexity of these models may limit their practicality in clinical practice