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Although the underlying mechanisms that lead to senescence within these models might be different, a general accepted paradigm is that the unrestrained proliferation elicited by an oncogenic event leads to the activation of tumour restraining events

Oral betaine administration was shown to decrease fasting glucose concentrations, improve insulin-resistance and thereby alleviate NAFLD in high-fat diet-fed insulin resistance NAFLD mouse models (Kathirvel et al., 2010