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Valimaki et al., 1990) Alcohol disrupts slow-wave sleep, the primary window for GH release (Ebrahim et al., 2013) Chronic alcohol use impairs hepatic IGF-1 production (Kopchick et al., 2014) Alcohol elevates cortisol, which opposes GH activity (Badrick et al., 2008) Growth hormone secretion is predominantly nocturnal and sleep-dependent (Van Cauter et al., 2000) Taken together, these findings provide a strong rationale for moderating alcohol intake during sermorelin therapy, even though occasional drinking is unlikely to cause significant problems