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However, other clues to the possibility of Wilsons disease include the presence of low serum uric acid (due to renal losses), low serum alkaline phosphatase (mechanism unknown), or a hemolytic anemia.2

The primary rationale for the therapeutic benefits of L-carnitine is its ability to restore normal oxidative metabolism and replenish energy stores in the myocardium

[25] NAD+ repletion restored NAD+ metabolic profiles, improved fat metabolism, lowered mitochondrial oxidative stress, and improved mitochondrial integrity in human cells with mutant WRN via restoring normal mitophagy

Statistical analysis performed using the Wilcoxon test