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Overview of IR The metabolites of chronic overnutrition, such as high glucose and non-esterified fatty acids (NEFAs), interfere with the activation of insulin receptor and its subsequent IRS-1/PI3K/Akt2 pathways, leading to the development of chronic inflammation in adipose tissue and ectopic lipid deposition in the liver and muscles, along with ERS and oxidative stress, etc

Circulation 116:15851595 Soriano FG, Virag L, Szabo C (2001) Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly- (ADP-ribose) polymerase activation

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