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Research has shown GHK-Cu influences expression of over 4,000 human genes, stimulates collagen I, III and elastin synthesis, activates matrix metalloproteinases for extracellular matrix remodelling, supports angiogenesis through VEGF and FGF upregulation, and suppresses pro-inflammatory TNF- signalling

Rather, the GSH pool remains rather constant while even marked increases in total glutathione are almost entirely due to the accumulation of GSSG (Smith et al., 1985