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NNMT is an enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide (NAM), producing 1-methylnicotinamide (MNA) and S-adenosylhomocysteine (SAH)

The trials tested oral, intravenous, and subcutaneous routes of administration at doses ranging from micrograms to 1 mg per day

As with any administered injectable or drugs, there are concerns about whether you require a prescription and whether the OHIP covers it

It is studied in preclinical models to investigate NNMTs role in metabolic regulation, NAD+ metabolism modulation, mitochondrial function effects, and potential metabolic benefits