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Two primary challenges impede their optimization: reliable induction of tinnitus and accurate behavioral assessment

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Prolonged exposure to laboratory lighting over six months causes measurable potency loss, though brief handling exposure has negligible impact

The broader systematic review of GLP-1 drugs in pain conditions [9] and the 2025 comprehensive review in the Journal of Headache and Pain [1] both conclude that the mechanistic case is plausible and interesting, but that human clinical trials with pain as the primary outcome are needed before we can make firm recommendations