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11 (1), e002137 (2024)
Activated astrocytes can shift toward different phenotypes: the A1 type, induced via NF-B signaling, produces proinflammatory mediators and can trigger neuronal apoptosis, whereas the A2 phenotype, driven by STAT3 activation, promotes anti-inflammatory and neuroprotective responses [32]
Advances in predictive, preventive, personalized, and participatory (P4) medicine, supported by genomics, multi-omics, imaging, and real-world data, are presented as accelerating biomarker discovery and enabling earlier and more precise stage-specific interventions
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