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Biochem J 49:593601 Marty L, Bausewein D, Mller C, Bangash SAK, Moseler A, Schwarzlnder M, Mller-Schssele SJ, Zechmann B, Riondet C, Balk J, Wirtz M, Hell R, Reichheld JP, Meyer AJ (2019) Arabidopsis glutathione reductase 2 is indispensable in plastids, while mitochondrial glutathione is safeguarded by additional reduction and transport systems

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20 Participants were randomized to saxagliptin groups at 2.5 mg, 5 mg, and 10 mg in combination with metformin doses ranging from 500 to 2,550 mg/day at study entry

Investigating the underlying molecular mechanisms, GHK-Cu was found to block critical signaling pathways